Removing one carotid body from some patients with high blood pressure can provide immediate and sustained fall in blood pressure, finds a new study.
Carotid bodies, a small cluster of chemoreceptors and supporting cells located near the fork (bifurcation) of the carotid artery that feed the brain with blood, appear to be a cause of high blood pressure. “The falls in blood pressure are impressive-- more than pharmacological medication -- and demonstrate the potential for targeting the carotid body to treat hypertension,” said Angus Nightingale, researcher at the University of Bristol, England.
The carotid bodies detect the levels of oxygen in blood and when this falls they raise the alarm of a potential emergency by signalling to the brain to increase breathing and blood pressure. “Treating the carotid body is a novel approach and a potential game changer as we believe we are reducing one of the main causes for hypertension in many patients. High blood pressure treatment typically tackles the symptoms targeting the end organs such as the heart, kidneys and blood vessels, and not the causes,” said Julian Paton, researcher at University of Bristol, England.
The clinical trial demonstrated that the carotid bodies in patients who responded to resection had raised carotid body activity. These patients breathed more at rest and produced exaggerated breathing responses when the oxygen level in their blood was lowered. “Although this surgical approach to controlling high blood pressure was successful, we don’t think this will be the solution in the long term. We now need to find a drug that dampens down an overactive carotid body and resets the blood pressure thermostat to a normal level,” Nightingale added.
“We are very excited by finding that we can turn down the alarm signals emanating from the carotid body in conditions of hypertension, yet it remains fully operational should an emergency situation occur. The new drug target we found within the carotid body is a receptor for ATP molecule called the P2X3 receptor.” explained Paton.
The research study was published recently in the Journal of American College of Cardiology: Basic to Translational Science.