A new study published in Nature reveals that common respiratory infections like Covid-19 and influenza can awaken dormant breast cancer cells in the lungs, potentially triggering metastatic tumors. The research, based on mouse models and human data analysis, highlights a concerning link between viral infections and cancer relapse among survivors.
Led by Julio Aguirre-Ghiso of Albert Einstein College of Medicine, the study found that inflammation caused by viruses activates disseminated cancer cells (DCCs) through a protein called interleukin-6 (IL-6). These cells, previously inactive, rapidly multiplied and formed lung metastases within two weeks of infection in mice.
The team also examined patient databases and discovered a higher risk of metastasis in cancer survivors following respiratory infections, especially within the first year post-infection. Researchers suggest that IL-6 inhibitors or targeted immunotherapies could help prevent such relapses.
Experts recommend that individuals with a history of cancer take precautions against respiratory viruses, including vaccination and regular consultations with healthcare providers