Since the time the world got affected by the COVID-19 virus, the medical community has been coming up with new ways to understand it better so that there can be effective treatments. Today, most researchers are developing mini-organs in the lab for studying the way the virus destroys the body. The studies taking place in such organoids include the gut, kidneys, liver, and lungs. That is not all. The researchers also experimented with the drugs in such small tissues to check whether the therapies would work correctly or not. It helps them to create a treatment model that works.
Having said that the medical community also propagates the relevance of vaccines and says getting vaccinated will not impose any limitation on individual freedom. According to a study in MyBioSource, 63% of people in Florida affirm to this thought. The number for Arkansas and Arizona is 53% and 57%, respectively.
The impact of SARS-CoV-2 on people
The doctors study hospitalized patients to understand how SARS-CoV-2 affects the body and damages the organs. However, no one knows for certain if all these damages occur directly by the virus or any second complexes caused by the infection. Today, several teams are using the organoid study to know how the virus affects the body and how it travels.
Generally, virologists study all the viruses using animal cells and cell lines that get cultured in the dish. However, it doesn’t replicate the SARS-CoV-2 infection correctly, as it doesn’t copy all that took place in your body.
The organoids are effective in explaining what SARS-CoV-2 can do to the human issue. It is possible for them to grow into various cell types and gradually assume the original organ shape within a few weeks. That aside, it is affordable compared to animal models and overlooks any ethical concerns.
However, the studies in the SARS-CoV-2 in the organoids come with the restriction as they don’t highlight the crosstalk between the organs in your body. According to Bart Haagmans, virologist, Erasmus MC in Rotterdam, it means, that the findings should get validated in the clinical studies and animal models.
The process of breathing in
An important finding from the organoids is all that the SARS-CoV-2 can do to the cells in your respiratory tract, right from the upper airway towards the lungs. Today, some leading virologists have come up with four cell types that get made using frozen cells from the epithelium or the external bronchial layer. As the team infected the organoids using the SARS-CoV-2, it was found that the virus typically targets the stem cells that can replenish the cells inside the epithelium, called the basal cells. These people shared their work and today want to study and research if the virus has the scope to move from the basal to other cells.
The blood rush
The SARS-CoV-2 can spread from the lungs to other organs. However, most researchers weren’t certain about the precise way the virus was moving until a while back. In certain medical experiments on the organoids, it was established that SARS-CoV-2 infects the endothelium, the cell linings and the blood vessels. After that, it enables the viral particles to leak into the blood and move through the body. The pathology reports of the damaged blood vessel in patients suffering from COVID-19 back up this hypothesis.
Additionally, further studies related to the organoids suggest that the moment it is in the blood, the deadly virus can infect many organs, including the kidneys. Even though infected kidney organoids and a few dead cells are present, it doesn’t testify whether that is the reason for a kidney ailment in certain patients.
The drug test bed
Some scientists are reading up about organoids and whether they can get used to assess the drugs that can work in this condition. The only hope is that today COVID-19 can get tested and there are many who have chosen clinical trials even before ample testing in animal and cell models. Also, owing to time sensitivity, the clinical trials were designed depending on the earlier know-how of the novel coronavirus and launched before a meticulous assessment of the model system. Hence, that could be the reason why most failed.
Doctors and scientists have approved 1,200 drugs from the FDA for various other ailments and discovered that cancer medicine Imatinib can suppress the SARS-CoV-2 in the lung organoid. There are other clinical trials where the treatment for the pandemic gets launched.
Furthermore, several other groups are testing the current drugs against the COVID-19 in the organoids with minimal success. One can fathom that towards the end of this method, there will be systems that test for drug efficacy and that it will be a long-run process. Hence, the mini organs are a beneficial factor for the medical community when treating the SARS-CoV-2 virus.